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KMID : 1037120140320030151
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The World Journal of Men′s Health
2014 Volume.32 No. 3 p.151 ~ p.158
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Effects of Hydro-Alcoholic Extract of Rhus coriaria (Sumac) Seeds on Reproductive Complications of Nicotinamide-Streptozotocin Induced Type-2 Diabetes in Male Mice
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Ahangarpour Akram
Oroojan Ali Akbar
Heidari Hamid
Ghaedi Ehsan
Nooshabadi Mohammad Reza Rashidi
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Abstract
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Purpose: The purpose of this study was to investigate the effects of the hydro-alcoholic extract of Rhus coriaria seeds on the reproductive system of nicotinamide-streptozotocin-induced type-2 diabetic mice.
Materials and Methods: In this experimental study, 56 male Naval Medical Research Institute mice were randomly divided into seven groups (n=8): control; diabetic mice; diabetic mice administered glibenclamide (0.25 mg/kg); diabetic mice who received the hydro-alcoholic extract of R. coriaria seeds (200 and 400 mg/kg groups); and normal mice who received this extract (200 and 400 mg/kg groups). Diabetes was induced by intraperitoneal administration of streptozotocin (65 mg/kg) 15 minutes after an injection of nicotinamide (120 mg/kg). Then, glibenclamide and the above mentioned extract were administered orally for 28 consecutive days. Twenty-four hours after the last treatment, serum samples, the testes, and the cauda epididymis were removed immediately for hormonal, testis morphology, and sperm parameter assessments.
Results: Body and testicular weight, sperm count and viability, and serum luteinizing hormone, follicle-stimulating hormone and testosterone levels were significantly lower in the diabetic mice (p＜0.05). The diabetic mice treated with 400 mg/kg of the hydro-alcoholic extract of R. coriaria seeds recovered from these reductions (p＜0.05). Further, glibenclamide alleviated hormonal and sperm count depletion in diabetes-induced mice (p＜0.05).
Conclusions: The present results indicated that the hydro-alcoholic extract of R. coriaria seeds has anti-infertility effects in
diabetic males.
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KEYWORD
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Diabetes mellitus, Nicotinamide, Spermatogenesis, Antioxidant effect, Streptozotocin
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